Resveratrol Combats Bone Marrow Cancer

11/04/2005

ODENSE, Denmark & MANHASSET, N.Y.--Two separate, recently published studies revealed resveratrol, a polyphenol found most notably in grapes and red wine, can help thwart bone marrow cancer myeloma.

Published in the Nov. 1 issue of Cancer Research (65:9943-52, 2005), the first study investigated the effects of resveratrol on multiple myeloma--accumulations of malignant plasma cells in bone marrow--as well as on osteoblasts (bone makers) and osteoclasts (bone destroyers), which determine the bone environment that factors in the survival of malignancy. The Dutch researchers found resveratrol (trans-3,4’,5 trihydroxystilbene) dose-dependently reduced the growth of myeloma cell lines (RPMI 8226 and OPM-2) via a cell apoptosis mechanism. Their in vitro study of resveratrol on human monocytes further showed inhibition of bone resorption by osteoclasts, while promoting expression of osteoblast markers, such as osteocalcin and osteopontin, in human bone marrow stem cells. They concluded resveratrol has potential to help treat multiple myeloma.

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