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To: MYELOMA Multiple Myeloma Support List, INTERNET:MYELOMA@LISTSERV.ACOR.ORG
From: brad rothkopf, 72277.3263
Date: 10/9/05, 7:46 PM
Re: myeloma medications
Message text written by MYELOMA Multiple Myeloma Support List
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Hi all,
I've been going through some of my research, and have compiled a list of drugs
available in the US and other countries by prescription, which have
demonstrated anti myeloma effect in vitro, and some are being studied in
trials. I tried to import them from word, but Mike explained to me that will
not work, so I will just list them in tabular form. This is not exhaustive,
just what I have found, and while I think it's correct, I can't always
guarentee accuracy. If anything looks of interest and furthur information is
desired, just email me or put it on the list, and I'll send anything I have. I
will put it in the tabular form below.
1. Type of Drug
2. Chemical class (if I know it)
3. Common name, (generic name)
4. Human trials (if I know)
Antiarthritic
NSAID (nonsteroidal antiinflammatory)
Celebrex (celecoxib), Lodine (etodolac)
yes
Antidiabetic
Thiazolidenedione, TZD
Avandia (rosiglitazone), Actos, (pioglitazone)
unaware
Antidepressent (various classes)
Wellbutrin (bupropion), Paxil (paroxetine), Seroquel (quetiapine), Anafranil
(clomipramine), Prozac (fluexitine)
unaware
Anti Aids (HIV) drugs
Protease inhibitors
Norvir (ritonavir), others
Reverse transcriptase inhibitors
Epivir (lamuvidine), and others
unaware
Antiestrogens
SERMS (selective estrogen modulators)
Nolvadex (tamoxifen), Evista (raloxifene)
yes, salvage therapy
Anticolitis drug
sulfapyridine salacylic acid
Azulfidine (sulfasalazine)
unaware
Anticholesterol drug
Statins
Zocor (simvastatin), Mevacor (lovastatin), Pravachol(pravastatin), Lipitor (atorvastatin)
Baycol),cerivastatin (withdrawn)
yes, mevacor, small Polish study, Lipitor, NIH, Zocor
Antiosteoporosis drugs
Aminobisphosphonates
Zometa, (zoledronic acid) Aredia (pamidronate), Boniva (ibandronate)
yes
Immunosuppresants (for organ transplants)
Various classes (Inosine mononphosphate dehydrogenase inhibitor)
Cellcept (mycophenolate)
Rapamycin (sirolimus)
Everolimus (certican in Europe, available p organ txpnt
yes, cellcept in trials
Antihypertensive
Phenylalkane
Isoptin (Verapamil (reduces resistance to other drugs)
Analogs being evaluated
Demethlyating agent
Vidaza (azacytidine)
no
Antileukemia drug
Gleevec (imitinib)
yes, ineffective in mm
Antiprotozoal
Suramin (unsure of generic name)
Stibogluconate (unsure of trade name)
yes
Anticoagulant
Defibrotide
yes, available in Italy
Vitamin D analogs
Paracalcitol (??), others
no
If anyone has information they'd like to add please do it. I'll try to update
this as new information becomes available. Remember, these are not
specifically antimm drugs, just drugs that are on the market that have an anti
mm effect in vitro, and of which they or their analogs may be under some degree
of study. I did not include nutraceutical, or nonprescription drugs
Regards,
Brad
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